When Straight-A college student Jeff Chang's two best friends take him out for his 21st birthday on the night before an important medical school interview, what was supposed to be a quick beer becomes a night of humiliation, over indulgence and utter debauchery.

Dr. Alex Cross is on his last police duty to track down an assassin called Picasso, who's been torturing and killing rich businessmen in Detroit. Soon when the mission gets personal, Cross is pushed to the edge of his moral and psychological limits to end this once and for all.

In the near future, Frank is a retired catburglar living alone while his successful son, Hunter, tries to care for him from afar. Finally, Hunter gets him a robot caretaker, but Frank soon learns that it is as useful as a burglary aide. As Frank tries to restart his old profession, the uncomfortable realities of a changing world and his worsening dementia threaten to take beyond what any reboot can do for him.